Monthly Archives: July 2018

Autoimmunity following Gardasil

Have you noticed how many young girls who have become so unwell following Gardasil  report the worsening of their symptoms after the second shot.

This research by Pompilio Martinez, MD from the School of Medicine, National University of Colombia explains why.

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Pompilio Martinez describes the neurological symptoms of 62 girls who were vaccinated against the human papilloma virus (HPV). The quadrivalent HPV vaccine Gardasil was given to 61 Colombian girls and and the bivalent Cervarix was administered to one Mexican girl.

Martinez’s survey reveals an overall pattern of peripheral nervous system damage as demonstrated by complaints of inflammatory and neuropathic pain syndromes in the head, back, chest, arms and legs. There were also sensory and motor syndromes with upper and lower limb numbness and tingling (paraesthesia), muscle weakness and difficulty walking (paresis) accompanied by tremors, muscle spasms and twitches (abnormal movements).

It was found that most of these debilitating symptoms developed after the second shot of the HPV vaccine which corresponds to the greater antibody titres that occurs after booster vaccines. Dr Martinez explains the common process of adding an aluminium adjuvant to the vaccine in order to strengthen the immune response and subsequent antibody production.

However as a result a serious problem can occur if antibodies attack other tissues in the body inducing a process called ‘molecular mimicry’.  These are called ‘cross-reacting’ antibodies or auto-antibodies and are capable of inducing disease in the body.

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Initial exposure to the vaccine or infection induces the production of immunoglobulin which increases over several weeks after vaccination. Then with a repeated dose of the vaccine body cells are reactivated causing very high antibody concentration. Importantly these cross- reacting antibodies are reactivated also and minor damage can be worsened.

Some of these examples of molecular mimicry manifest as nerve demyelination and are experienced as muscle weakness, numbness and neuropathic pain. Some very unfortunate girls and boys develop respiratory muscle problems and require intubation and ventilation.

One of the striking findings of the survey was that symptoms developed after the second dose of the HPV vaccine. After the first dose only 15-30% of girls had symptoms but 48-80% were symptomatic after second dose. Symptom onset and disease severity increase with doses because of increased antibody titres.

This is what we are seeing in the girls who have become unwell after 2 or 3 doses of Gardasil. Frequently their stories are of worsening disease after the second dose of Gardasil.

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In my book Gardasil: Fast-Tracked and Flawed I wrote about Australian woman Kristin Clulow and her battle with ill health following Gardasil. In May 2008, the 26-year-old Australian woman received the first dose of Gardasil, one of the human papilloma virus (HPV) vaccines on the market. Two weeks later, the fit young woman fell and broke her left foot and although perplexed at the ease at which she had incurred her fracture, she didn’t think the two events were connected. In August 2008, she dutifully turned up at her doctor’s office for her second shot of Gardasil. But shortly after this injection, Kristin’s health began to unravel. It started with a temporary loss of vision and mobility problems that made it impossible for her to run, jump, dance or wear her beloved heels. Then her handwriting failed her: “Handwriting just doesn’t suddenly go,” she cried. Worse was to come when Kristin’s speech became slurred: “They thought I’d had a stroke.” Kristin’s story is all too common with adverse effects following the HPV vaccines now well over 80,000 according to the World Health Organisation’s database.

Interpretation of the study

We can infer that auto-antibody concentration paralleled symptoms suffered by girls who became sick by Gardasil. That is, antibodies elicited by the first dose caused symptoms in a few girls; while greater antibody concentrations with a second dose would cause a greater number of them to fall sick. Although we have no lab evidence of antibodies changing in this fashion we don’t need it, since it’s a very well-established scientific fact that serum antibody titres change with vaccine doses

Clinical evidence

In the study it was found that when the girls were re-exposed to vaccine antigens the auto-antibodies rose and relapse occurred. When the auto-antibodies were removed then there was clinical improvement. Partial remission has been achieved with antibody removal therapies such as IVIg ( a solution of human plasma proteins and plasmapheresis (a process that filters the blood and removes harmful antibodies).

Valentina’s story

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After two doses of Gardasil, Valentina developed flaccid paralysis in at least five muscle groups in her body. The young Colombian woman could not breathe and was intubated and ventilated and given plasmapheresis ridding her blood of the autoantibodies that had caused her paralysis.

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This procedure is used for treating many autoimmune diseases which are increasing rapidly. It is not a treatment that is undertaken lightly with risks of  complications as well as costing thousands of dollars. This is why there has to be more independent research such as what has been elicited by Martinez in Colombia. It is vital that the public understand the risks of these vaccines that are being given to teenagers all over the world.

How can we let this happen? All over the world girls and boys are becoming very ill after being vaccinated against HPV said to causing cervical cancer. But there is no scientific proof that the vaccine has ever prevented a single case of the cancer. Cervical cancer is well detected by Pap smear programs. There is no need for these harmful vaccines.

 

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Cervical cancer is not a rare event in Australia

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Last week Professor Ian Frazer received an honorary fellowship from the Royal College of Physicians in Ireland. In an address the immunologist and co-developer of Gardasil told his audience:

“It is such a rare event in Australia to get a cancer now”

Did anyone question him about this ?

All it takes is a simple search to dispute the professor’s statement.

Seriously how does he get away with saying this when this is so blatantly untrue.

According to Cancer Australia it is estimated that 930 women will be diagnosed with cervical cancer this year and that 258 of these will die.  In 2013, there were 813 new cases of cervical cancer diagnosed in Australia.

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The incidence and mortality of cervical cancer was falling well before HPV vaccination which commenced in Australia in 2007. The welcome decline was due to improved living conditions followed by advent of the Australian National Pap smear program which began in 1991.

Ian Frazer along with his co-developer the late Jian Zhou are responsible for the creation of this genetically engineered HPV vaccine purported to prevent cervical cancer. The marketing of this vaccine was intense and aimed at young women who were made fearful about a disease they had scarcely heard of, let alone likely to develop. Ian Frazer vaccinated the first Australian girl in 2007.

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But there is no scientific proof that the vaccine has ever prevented a single case of the disease. However there is evidence of the rising amount of illness and death following the worldwide rollout of Gardasil with the World Health Organisation’s Vigibase recording over 80,000 serious adverse events. And all because of a vaccine that they did not need and that is said to prevent a disease that they were unlikely to ever develop. Tragic!

Inclusion of the boys in the vaccination programs

Slowly and surely boys are being included in HPV vaccination programs.  At present there are 84 government-funded HPV vaccination programmes where 18 countries which include Canada, Slovenia, the United States, New Zealand, Australia and Italy are now vaccinating boys along with girls. In April this year the Irish government joined these countries and voted to include the HPV vaccine for teenage boys.

And this week the UK reversed its previous decision not to vaccinate the boys with the government advisory body on immunisation concluding that vaccination against the cervical cancer-causing human papilloma virus (HPV) should be extended to boys.

Why is this given to boys when clearly they do not get cervical cancer? The reason given is that HPV is supposedly responsible for 60 per cent of mouth and throat cancers.

Who is behind the campaign to extend HPV vaccination to UK boys?

Behind the scenes is the Scottish charity, the Throat Cancer Foundation which has been running a campaign “Jabs For The Boys.” And guess who was on the charity’s clinical and scientific board. Well it’s our very own ‘national hero’ Professor Ian Frazer the co-developer of Gardasil and who was awarded the honour of ‘Australian of the Year’ in 2006. Ian Frazer is no longer on the board.

Then there is the obvious conflict of interest in Professor Margaret Stanley a consultant for Gardasil’s manufacturer Merck remaining on the charity’s board.

Her presence on the advisory board of the Throat Cancer Foundation indicates high-level industry support and influence.

Lately I have been noticing a trend that in articles pertaining to HPV vaccines there is no mention of Gardasil by name.

Reading from the UK Independent 

Vaccination against the cervical cancer-causing human papillomavirus (HPV) should be extended to boys, the government advisory body on immunisations has recommended. After an inquiry into the cost-effectiveness of broadening the HPV jab programme, the Joint Committee on Vaccination and Immunisation (JCVI) backed a “gender neutral” scheme. Since 2008, HPV vaccination has been routinely offered to girls aged 12 to 13 at secondary school and is free on the NHS up until their 18th birthday, but there have been growing demands to extend immunisation to boys.

Is Gardasil’s troublesome past precluding its reference?

And could it have anything to do with the fact that Merck   is having to defend itself from an accusation of fraud, deceit and negligence in a US Gardasil case?

In July 2016, a case was filed in the Superior Court of the State of California, Los Angeles County (central district). The case involved a 16-year-old female who between 2010 and 2011 received three injections of Gardasil, the HPV vaccination manufactured by Merck. Shortly after she received her third vaccination, she suffered a severe adverse reaction, the nature and complexity of which, failed to be diagnosed until 2015, when she finally received the diagnosis of Postural orthostatic tachycardia syndrome (POTS).

The young girl’s family are resolute in their belief that the vaccinations caused her illness. Prior to her HPV vaccination she was a very active teenager.  It will be very interesting to see how this case proceeds. Read more about it here.

 

 

 

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Injected And Neglected – Irish Gardasil Protest

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You couldn’t make this stuff up.

Two young Irish girls protesting against Gardasil a few days ago suffered seizures and needed hospital care, while inside the nearby Royal College of Physicians of Ireland, Professor Ian Frazer the co-developer of the vaccine was giving a speech and spruiking the ‘success’ of the Australian HPV vaccination program. Continue reading

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Pancreatitis after Gardasil: not a novel entity

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Bizjak et al report on the case of a 20 year-old male who developed severe abdominal pain 1 week after being vaccinated with Gardasil. Although still suffering with ongoing nausea and pain, he received his second shot of the HPV vaccine.

Only 10 days later, laboratory results revealed significantly elevated pancreatic enzymes, and with concomitant abdominal pain and vomiting, he was diagnosed with acute pancreatitis.

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The researchers report that this case of acute pancreatitis following HPV vaccination ‘is not a novel entity‘ They cite the case of a 26 year-old woman who developed epigastric pain 4 days after her first dose of Gardasil. The examination of the woman excluded other causes of pancreatitis with the only other likely causation in a previously healthy young woman to be the HPV vaccine.

In 2008 Dr Renate Klein wrote in The Gardasil ‘miracle’ coming undone? , that the Therapeutic Good Administration (TGA) had announced an investigation into a possible link between Gardasil and the development of pancreatitis in young women after their HPV vaccination. Klein welcomed the news of the inquiry and added that while the TGA was at it they should also look in detail at the other adverse effects that have been reported in Australia and around the world. These total over 83,000 serious adverse events and over 400 deaths.

News of the TGA review into pancreatitis and HPV vaccines came after reports that three Australian young women had become very ill with pancreatitis soon after receiving the injection.

Dr. Amitabha Das and several colleagues claim that three female patients injected with the quadrivalent medication were later diagnosed with pancreatitis. They reported that they were unable to find another cause for pancreatitis and that a possible link to the HPV vaccine needed to be excluded.

Pancreatitis

Pancreatitis is inflammation of the pancreas. The pancreas is a very important organ responsible for producing digestive juices and certain hormones, including insulin responsible for regulating blood sugar. Symptoms include sudden, severe upper abdominal pain, often spreading through to the back, along with nausea, vomiting, fevers, sweats and a tender abdomen.

Molecular mimicry

Possible mode of causation is by the process of molecular mimicry. In their paper Pancreatitis after human papilloma vaccination: a matter of molecular mimicry  the authors state:

In conjunction with aluminum adjuvant, the induction of immunity through molecular mimicry may potentially culminate in production of cytotoxic autoantibodies with a particular affinity for pancreatic acinar cells.

Molecular mimicry
We have proteins in our bodies and within these proteins there are 82 peptides. One of the antigens in Gardasil is the HPV 16 LI protein which almost identically matches 34 of these peptides. The importance of this information is that as Norma Erickson explains:

It is extremely possible that when you develop an antibody to the HPV 16 protein you are also developing an antibody reaction to your own system in multiple locations. The number of viral matches and locations makes the occurrence of autoimmune cross reactions in the human body following HPV 16 vaccination almost unavoidable.

Phillipa described herself as a healthy young woman who exercised daily, ate well and did not take drugs and rarely drank alcohol. But in October 2007 she experienced an attack of pancreatitis which at the time she thought was a gastro virus. As the pain eventually subsided, she experienced chest and shoulder pain which persisted for 24hrs. Her doctor blamed it on a virus. Around three months later the abdominal pain returned and again two months later at which stage she was tested and found to be suffering from pancreatitis.

Phillipa became aware that there might be a link between her vaccination with Gardasil and her new disease after her mother heard an ABC radio report that the TGA was investigating three cases of young girls experiencing pancreatitis after having had their Gardasil injections.

Phillipa checked the dates of her Gardasil injections to see if they coincided with her pancreatitis and found that her first vaccine given on 04/08/07 did not cause any overt problem but her second given on 06/10/07 was nine days before her first attack and the third on the 17/04/08 was 3 days before her third attack of pancreatitis. She reported this to the TGA.

One of her attacks resulted in an emergency trip to the hospital where she was given intravenous fluids and remained an inpatient for four days.

She had 4 attacks of pancreatitis over the year …two of which occurred days after she received the Gardasil shots. She believes that her pancreatitis was because of her Gardasil vaccine.

The TGA inquiry?

Did the TGA conduct a review into Gardasil and links to pancreatitis? I have tried to find out but despite phone calls and emails I have not been able to discover whether an inquiry was performed. Also I could not find any recent cases of pancreatitis after Gardasil on the adverse events database. Makes me wonder if the disease has been reclassified on the the TGA’s database of adverse events in the general category of  gastrointestinal disorders. Screen Shot 2018-07-08 at 3.14.35 PM

Gastrintestinal disorders doesn’t sound as serious as pancreatitis. Vomiting and nausea sound fairly innocuous but are they a symptom of a more dangerous health condition such as pancreatitis? Many questions need to be asked of the TGA, Australia’s regulatory authority for therapeutic goods. But then with the TGA wholly funded by the industry it administers we should not hold our breaths.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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